What are words for

1 05 2014

I like Charlie Pierce.

I like his laugh on Wait Wait Don’t Tell Me, and even more so, I like his writing on his Politics blog at the Esquire site.

He can be too much sometimes, but as someone who is rather constantly afraid of her own too-muchness, I appreciate his own constant willingness to lay it out there.

I don’t agree with his take on everything and sometimes roll my eyes at the repetitious “zombie-eyed granny starver” (Paul Ryan) and “goggle-eyed homunculus hired by Koch Industries to manage their midwest subsidiary formerly known as the state of Wisconsin” (Scott Walker), tho’ I do admit to smirking at “Our Magic Lady of the Dolphins” (Peggy Noonan).

But this is a guy who has fun writing, and who’s always willing to toss out bits of verbal absurdity, to whit “up with which I will not put”. (See most recent deployment of this phrase here.)

I don’t know why that so delights me, but it does. That’s enough.

And yes, I got a kick out it even before my brain began turning into hash.

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I don’t wanna talk about it now

20 12 2013

Late late, so quick quick:

I’m with Charlie Pierce on this issue: just because our courts have concluded that the First Amendment doesn’t (necessarily) extend to the private sphere doesn’t mean the rest of should so blithely dismiss concerns about free speech which one’s employers don’t like.

This deserve more thoughts than I have at the moment, but. . . yeah.

Maybe it ain’t censorship, but that don’ make it right.





12 08 2013

What Charlie Pierce said:

Over on CBS, former Toussaint L’Ouverture embed Bob Schieffer talked a lot of NSA with a lot of people whose careers depended on the surveillance state, but managed to keep his show blessedly free of fringe congresscritters. But General Michael Hayden admitted that he got a little a’skeer’ed a couple of weeks ago when democracy threatened to break out in the House over the NSA programs.

GENERAL MICHAEL HAYDEN: You’re referring to the vote, on a twelve-vote margin a couple of weeks back. Bob, that wasn’t— that wasn’t regular order. That wasn’t thoughtful procedure. Let me be a little critical here, all right. That looked a lot like mob action. I mean people acting out of emotion with a false sense of urgency, and with a great deal of misinformation.

I’m not great fan of the House Of Representatives as it is presently constituted. There’s far too much Gohmertian nonsense for my taste, but when a career spook starts talking about a perfectly legitimate legislative process as a “mob action,” I find that I have better things to be nervous about than Steve King.

And need I point out the General Fear-Mongerer had no problem with “emotion” and “a great deal of misinformation” in the passage of the PATRIOT Act, nor with “a false sense of urgency” in the run-up to the Iraq War?

Rat bastard in a uniform.





Stop me if you think you’ve heard this one before

18 03 2013

Oh that Rand Paul, champion of liberty! Look how he’s standing up for freedom now:

“The Life at Conception Act legislatively declares what most Americans believe and what science has long known – that human life begins at the moment of conception, and therefore is entitled to legal protection from that point forward,” Paul said in a statement. “ The right to life is guaranteed to all Americans in the Declaration of Independence and ensuring this is upheld is the Constitutional duty of all Members of Congress.”

Ahh, conceptional personhood: An idea utterly lacking in biological sense.

Charlie Pierce has the right idea regarding the Paul family: His Five Minute Rule  states that, for five minutes, both the son and the father, Crazy Uncle Liberty (!), make perfect sense on many issues. At the 5:00:01 mark, however, the trolley inevitably departs the tracks.

As Pierce notes, with this we are at the 5:00: 07 mark: The trolley has jumped the tracks, tipped over on its side, and is skidding down the boulevard.

I believe I have covered this before, but let’s go over this again, shall we?

There is no such thing as the “moment of conception”.

As Moore and Persaud note in the 6th edition of The Developing Human: Clinically Oriented Embryology:

Fertilization is a complex series of “coordinated molecular events (see Acosta, 1994 for details) that begins with the contact between the sperm and a oocyte and ends with the intermingling of maternal and paternal chromosomes at metaphase of the first mitotic division of the zygote, a unicellular embryo. Defects at any stage in the sequence of these events might cause the zygote to die (Asch et al, 1995). . . . The fertilization process takes about 24 hours. [p. 34, emph added]

“Process”, Senator Paul, not “moment”. Shall we break it down even further?

  • Passage of sperm through corona radiata surrounding the the zona pellucida of an oocyte.
  • Penetration of the zona pellucida surrounding the oocyte
  • Fusion of plasma membranes of the oocyte and sperm
  • Completion of the second meiotic division of oocyte and formation of female pronucleus
  • Formation of male pronucleus
  • Membranes of pronuclei break down, the chromosomes condense and become arranged for a mitotic cell division—the first cleavage division [pp. 34-36]

There are many more details involved in those stages, but the highlights ought to be enough.

At this point, the zygote is still in the ampulla [middle portion] of the fallopian tube, ambling its way toward the uterus. Beginning around 30 hours post-fertilization, it undergoes a series of mitotic or cleavage divisions, in which the internal cells (blastomeres) divide and become successively smaller. “After the nine-cell stage, the blastomeres change their shape and tightly align themselves against each other to form a compact ball of cells. . . . When there are 12 to 14 blastomeres, the developing human is called a morula (L. morus, mulberry).”  The morula forms about 3 days post-fert, and enters the uterus 3-4 days post-fert. [p. 41]

Okay, 4 days in and the mulberry is still wandering around, unattached, developing away. A fluid filled space called the blastocyst cavity or blastocoel forms, which separates the blastomeres into two parts:

  • a thin outer cell layer called the trophoblast, which gives rise to the embryonic part of the placenta
  • a group of centrally located blastomeres known as the inner cell mass, which gives rise to the embryo [p. 41]

At this point the berry becomes a blastocyst. (FYI: If you are an embryonic stem cell researcher, this is when you’d harvest the inner cell mass in order to cultivate stem cell lines. The blastocyst would, of course, be destroyed in the process.)

The blastocyst continues to float around in “uterine secretions” for a couple of days as “the zona pellucida gradually degenerates and disappears”. [p. 41] With the dissolution of the zona pellucida, the blastocyst is free to bulk up on those tasty secretions, until around day 6 post-fert, when it attaches itself to the endometrial epithelium.

All hell breaks loose now, as the trohoblast differentiates itself and its outer layer, the syncytiotrophoblast, insinuates itself into the endometrial epithelium and into the connective tissue, or stroma. “The highly invasive syncytiotrophoblast expands quickly adjacent to the inner cell mass, the area known as the embryonic pole. The syncytiotrophoblast produces enzymes that erode the maternal tissues, enabling the blastocyst to burrow into the endometrium.” [p. 42]

Although it takes another week for the embryo to implant itself fully into the endometrium and stroma—which further details I will spare you—this is the stage at which one could say a pregnancy begins.

Got it? One day for the process of fertilization, 6 days for sufficient development to begin a pregnancy, for a grand total of 7 days or one week.

Oh, and one more thing: Of all the zygote-morula-blastocysts formed, 25 percent wash out before implantation, and another 35-55 percent miscarry before birth. Only 20-40 percent of those berries results in a baby.

Anyway, if I wanted to be kind to the momentary conceptional folks, I could say that “conception” is achieved after 24 hours; if I wanted to be strict, I could say 7 days, and if I wanted to be a real bitch, I could argue that not until 14 days has the embryo done anything worth considering a “conception”. Even granting a kindness, it’s clear that the moment is, at its shortest, a day.

Why does this matter? After all, for many people who are pro-life, the issue is less the biology than the morality; that the conceptus takes awhile to get itself together does not obviate the fact that the process begins—that human life begins—when the sperm drills itself into the egg. The biology matters only because it is a trigger for something more, not in and of itself.

This, of course, is how you get bullshit proposals like personhood bills and amendments: by treating biology as a chit in the culture war rather than a reality on its own terms.

Human development is an amazing, complicated, and fraught process, one which does not comport itself easily to our moral preconceptions (sorry) about it. By all means, make a moral argument, but don’t pretend that biology tucks up neatly into it.

Senator Paul is free to believe all he wants “that human life begins at the moment of conception, and therefore is entitled to legal protection from that point forward”, but I am also free to point out it is a belief untethered to biological reality.

That trolley done run into nonsense.